The “Knee Biofeedback Rehabilitation Interface for Game-based Home Therapy (KneeBRIGHT)” system combines electromyography (EMG) biofeedback with video game therapy to provide knee osteoarthritis (OA) patients with an engaging, effective tool for conducting rehabilitation exercises at home. Barron Associates has completed a randomized control clinical trial to assess the efficacy of the KneeBRIGHT system at improving function for knee OA patients. The study compared the exercise adherence and strength improvements of patients who completed 10 weeks of exercise using the KneeBRIGHT game (intervention group) with patients who completed 10 weeks of traditional rehabilitation exercise (control group). Thirty-two participants with knee OA completed the study. Increases in strength, pain, and balance measures increased across all participants after the 10-week regimen. Participants who used the KneeBRIGHT system expressed enthusiasm for using a game to guide their exercise routines.